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1990年4月至1992年4月,我们应用盐酸纳洛酮治疗急性酒精中毒患者44例,并与随机选择用传统治疗方法治疗的44例作疗效对比观察,现将结果报告如下。 1 临床资料 1.1 一般资料盐酸纳洛酮治疗组(治疗组)44例,男38例,女6例;年龄16～43岁,平均26.8岁。传统方法治疗组(对照组)44例,男40例,女4例;年龄15～45岁,平均27.3岁。 1.2 饮酒量与中毒分期(见表1)本组按急性酒精中毒三期分组:兴奋期、共济失调期、昏睡及昏迷期。 1.3 治疗方法患者入院后酌情洗胃,保暖,补液。治疗组在此基础上应用盐酸纳洛酮(naloxonehydrochloride,军事医学科学院毒物药物研究所研制,0.4 mg/支)0.4mg加生理盐水10 ml,给兴奋期患者静脉注射。对共济失调期患者则用0.8 mg加生
April 1990 to April 1992, we applied naloxone Hydrochloride in 44 patients with acute alcoholism, and randomly selected with the traditional treatment of 44 cases compared to the efficacy of the treatment, the results are reported as follows. 1 Clinical data 1.1 General Information Naloxone hydrochloride treatment group (treatment group) 44 cases, 38 males and 6 females; aged 16 to 43 years, mean 26.8 years. The traditional treatment group (control group) 44 cases, 40 males and 4 females; aged 15 to 45 years, mean 27.3 years. 1.2 alcohol consumption and poisoning staging (see Table 1) The group divided into three groups according to acute alcoholism: excitement, ataxia, lethargy and coma. 1.3 Treatment of patients as appropriate, gastric lavage after admission, warm, rehydration. On the basis of this, the treatment group was given intravenous injection of naloxonehydrochloride (0.4 mg / support, 0.4 mg / support) and 10 ml of normal saline for the excitement phase. In patients with ataxia 0.8 mg plus students