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一氧化氮（ＮＯ）在体内许多病理生理过程中发挥了重要作用。急性肺损伤时，内源性ＮＯ的大量合成可导致血管扩张、心肌收缩力下降等损害，但内源性ＮＯ可降低肺动脉压、减少血小板粘附及白细胞出游。ＮＯ供体及ＮＯＳ抑制剂在急性肺损伤中亦表现出有利及有害两方面的作用，ＮＯ在临床上的应用价值还有待进一步研究
Nitric oxide (NO) plays an important role in many pathophysiological processes in the body. Acute lung injury, a large number of endogenous synthesis of NO can lead to vasodilation, myocardial contractility decreased damage, but endogenous NO can reduce pulmonary artery pressure, reduce platelet adhesion and leukocyte travel. NO donors and NOS inhibitors also show both beneficial and detrimental effects in acute lung injury. The value of NO in clinical application remains to be further studied