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用山莨菪碱（６５４－２）防治蛛网膜下腔出血（ＳＡＨ）后脑血管痉挛，观察６５４－２对基底动脉中ＥＤＲＦ，ＭＤＡ，ＳＯＤ，ｃＧＭＰ，Ｃａ￣（２＋），Ｎａ￣＋的影响。结果表明，应用６５４－２后降低了基底动脉中ＭＤＡ产生及Ｃａ￣（２＋）Ｎａ￣＋的含量，与ＳＡＨ组比，ＥＤＲＦ释放增加，ＳＯＤ活性及ｃＧＭＰ水平提高，基底动脉内皮细胞受到保护，基底动脉收缩幅度减小。提示，６５４－２可通过保护内皮细胞，减轻氧自由基损伤，拮抗Ｃａ￣（２＋）Ｎａ￣＋在细胞内的蓄积，从而促进内皮细胞ＥＤＲＦ释放，引起血管舒张，明显减轻ＳＡＨ后的脑血管痉挛。
The effects of 654-2 on EDRF, MDA, SOD, cGMP, Ca ~ (2 +) and Na ~ + in basilar artery were observed by using anisodamine (654-2) to prevent cerebral vasospasm after subarachnoid hemorrhage (SAH). The results showed that the application of 654-2 decreased the production of MDA and the Na ~ + content in basilar artery. Compared with SAH group, EDRF release increased, SOD activity and cGMP level increased, basilar artery endothelial cells were protected, Basilar artery contraction amplitude decreases. These results suggest that 654-2 can protect endothelial cells and reduce the damage of oxygen free radicals and antagonize the accumulation of Ca ~ (2+) Na ~ + in the cells, thereby promoting the release of EDRF in endothelial cells, causing vasodilation and obviously relieving cerebrovascular Spasm.