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儿茶酚胺类物质在维持循环和代谢内环境的稳定中起重要作用。正常分娩新生儿交感神经系统已充分发挥其功能作用,2岁以下小儿游离去甲肾上腺素和肾上腺素水平高于成人3倍以上,窒息、心力衰竭时儿茶酚胺将成倍增加。α、β受体生后即已成熟,故用β受体激动剂多巴胺(DOP)和多巴酚丁胺(DOB),对心功能改善有较好效果。本文就DOP与DOB临床应用的作用机理和血液动力学效应加以阐述。DOB在新生儿和儿童中的应用还有待进一步积累经验和探索。
Catecholamines play an important role in maintaining circulatory and metabolic homeostasis. Normal delivery neonatal sympathetic nervous system has its full function, 2-year-old children free norepinephrine and adrenaline levels higher than adults more than 3 times, asphyxia, heart failure, catecholamines will be doubled. α, β receptors mature after birth, so the use of β-agonists dopamine (DOP) and dobutamine (DOB), to improve cardiac function better. This article describes the DOP and DOB clinical application of the mechanism of action and hemodynamic effects are described. The application of DOB in newborns and children remains to be further accumulated experience and exploration.