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目的 探讨不同剂量的奥美拉唑及西米替丁对十二指肠球部溃疡 (DU)病人胃内pH的影响。方法 采用随机对照的临床研究方法。 4 0例DU病人随机分为 5组 ,每组 8人 ,分别接受①每天 1次静脉注射160 0mg西米替丁 ;②每天 1次静脉注射 4 0mg奥美拉唑 ;③每 12h 1次静脉注射 4 0mg奥美拉唑共 2 4h;④首剂 4 0mg奥美拉唑静脉注射 ,然后以 8mg/h的滴速持续滴注 2 4h ;⑤首剂 4 0mg奥美拉唑静脉注射 ,然后以 4mg/h的滴速持续滴注 2 4h。在用药期间连续 2 4h监测其胃内pH值。结果 后 4组用法均能迅速提高病人的胃内pH值至 6 0 ,其平均胃内pH值分别为 :5 8± 1 3 ,6 91± 0 65 ,6 84± 0 4 5 ,6 81± 0 3 6;pH≥ 6 0时间占整个用药全程的百分比分别为 3 5 8% ,83 3 % ,84 5 % ,85 6% ;而西米替丁则需较长时间方能提高胃内pH值至 6 0 ,其平均胃pH值为 5 4± 1 6,pH≥ 6 0的时间占整个用药全程的 3 0 6%。结论 奥美拉唑能快速提高胃内pH值至 6 0 ,但每天 2次静脉注射 4 0mg和持续静脉滴注能维持稳定的较高的胃内pH值
Objective To investigate the effects of different doses of omeprazole and cimetidine on gastric pH in patients with duodenal ulcer (DU). Methods Randomized controlled clinical research methods were used. Forty DU patients were randomly divided into 5 groups of 8 patients each receiving 1 mg intravenous 160 mg cimetidine once daily, omeprazole 40 mg intravenously once daily, Injection of 40mg omeprazole a total of 2 4h; ④ the first dose of 40mg omeprazole intravenous injection, and then drip 8mg / h drip infusion for 24 hours; ⑤ first dose of 40mg omeprazole intravenous injection, and then The drip rate of 4mg / h continued infusion 24 h. During the treatment of 24h continuous monitoring of their gastric pH. Results All the four groups of patients were able to rapidly increase the intragastric pH value to 60, and the average intragastric pH value was 581 ± 631 ± 65, 6 84 ± 0 45, 6 81 ± 0 3 6; the percentage of pH≥ 60 during the whole course of treatment was 35.8%, 83 3%, 84 5% and 85 6%, respectively; while cimetidine needed longer time to increase gastric pH The average gastric pH was 54 ± 16, and the time of pH≥60 was 30.6% of the whole medication. Conclusion Omeprazole can quickly increase the intragastric pH to 60, but intravenous infusion of 40 mg twice daily and continuous intravenous infusion can maintain stable and high intragastric pH