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目的:探讨大肠癌患者血清降钙素原(Procalcitonin,PCT)水平与肝转移的关系。方法:回顾性分析我院2013年01月-2015年12月收治的大肠癌患者101例,按照远处转移情况分为三组:无远处转移组(A组)55例、仅肝转移组(B组)27例以及除肝脏以外其他远处转移组(C组)19例,采集相关临床、PCT、生化以及肿瘤指标等资料。结果:三组间PCT水平分别为0.16(0.07-0.28)ηg/m L、1.20(0.32-2.89)ηg/m L以及0.67(0.12-1.23)ηg/m L。B组PCT水平明显高于A组,差异具有统计学意义(p<0.05)。PCT与大肠癌肝转移呈正相关关系,β=0.577,p=0.002。ROC曲线显示PCT诊断大肠癌肝转移的最佳切点是0.56ηg/m L,敏感性66.7%,特异性92.7%。结论:大肠癌患者PCT升高与大肠癌肝转移密切相关,可作为诊断大肠癌肝转移的一个有效指标。
Objective: To investigate the relationship between serum procalcitonin (PCT) level and hepatic metastasis in patients with colorectal cancer. Methods: A retrospective analysis of 101 patients with colorectal cancer admitted to our hospital from January 2013 to December 2015 was divided into three groups according to the distant metastasis: 55 cases without distant metastasis group (A group), only liver metastasis group (Group B) and 19 cases of distant metastasis group (group C) except the liver. The clinical, PCT, biochemical and tumor indexes were collected. Results: PCT levels were 0.16 (0.07-0.28) ηg / m L, 1.20 (0.32-2.89) ηg / m L and 0.67 (0.12-1.23) ηg / m L respectively among the three groups. The PCT level in group B was significantly higher than that in group A, the difference was statistically significant (p <0.05). PCT and liver metastasis of colorectal cancer was positively correlated, β = 0.577, p = 0.002. The ROC curve showed that the best cut-point for the diagnosis of hepatic metastases by PCT was 0.56ng / m L, with a sensitivity of 66.7% and a specificity of 92.7%. Conclusion: The elevated PCT in patients with colorectal cancer is closely related to the liver metastasis of colorectal cancer, which may be used as an effective indicator in the diagnosis of liver metastasis of colorectal cancer.