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目的:探讨泮托拉唑抑制胃溃疡胃酸分泌的疗效及安全性评价,从而提高第三代质子泵抑制剂的临床应用水平。方法:选择2013年1月至2014年11月中山市东凤人民医院120例使用泮托拉唑的患者,观察药物抑制胃溃疡胃酸的分泌情况,及治疗后患者症状改善情况及不良反应的发生率。结果:泮托拉唑的治愈率为72.5%,临床有效率为85.8%,能够明显缓解患者的腹胀、嗳气、反酸等症状,不良反应的发生率仅为2%,老年不良反应发生率为8%,长期治疗不良反应发生率2%。结论:泮托拉唑可安全高效抑制胃酸的分泌,缓解临床症状,健全的风险评估管理体系可安全有效的使用药物。
Objective: To investigate the efficacy and safety of pantoprazole in inhibiting gastric acid secretion in gastric ulcer, so as to improve the clinical application of the third generation proton pump inhibitor. Methods: From January 2013 to November 2014, 120 patients with pantoprazole in Dongfeng People’s Hospital of Zhongshan City were enrolled in this study. Gastric acid secretion was observed in patients with gastric ulcer and the symptom improvement and adverse reactions were observed after treatment rate. Results: The cure rate of pantoprazole was 72.5% and the clinical effective rate was 85.8%. It could relieve the symptoms of abdominal distension, belching, acid reflux and other symptoms. The incidence of adverse reactions was only 2%. The incidence of adverse reactions in the elderly was 8%, long-term treatment of adverse reactions occurred in 2%. Conclusion: Pantoprazole can safely and efficiently inhibit gastric acid secretion, relieve clinical symptoms, and improve the risk assessment management system to use drugs safely and effectively.