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目的探讨3.0T MRI多回波(multi-echo,ME)Dixon技术对非酒精性脂肪性肝病(NAFLD)患者的肝脏脂肪定量分析的可行性。方法前瞻性地纳入自愿加入本研究的志愿者20例,其中女性NAFLD患者4例,正常对照者1例;男性NAFLD患者12例,正常对照者3例。进行常规肝脏MRI平扫、ME序列检查,之后再进行单体素磁共振波谱分析(MRS)检查。检查结束后处理数据,记录Screening Dixon的脂肪分数(fat fraction,FF)值和Histo序列自动得出的单体素MRS的FF值,再手动在ME Dixon的FF图中测得3个感兴趣区(ROI)的FF值。最后分别对各FF值进行Spearman相关性分析。结果Screening Dixon与ME Dixon的3个ROI区域测得的FF值呈高度正相关(r=0.842、0.959、0.945,P值均<0.001)。Screening Dixon及ME Dixon的3个ROI区域测得的FF值与Histo得出的单体素MRS所测得的FF值呈高度正相关(r=0.971、0.842、0.959、0.945,P值均<0.001)。结论采用3.0T MRI ME Dixon成像技术对NAFLD患者进行肝脏脂肪含量的评估是可行的,并与单体素MRS所得结果呈高度正相关。其结果对于NAFLD患者的诊断、随访和干预监测均具有一定的临床价值。
Objective To investigate the feasibility of quantitative liver fat analysis in patients with non-alcoholic fatty liver disease (NAFLD) by 3.0T MRI multi-echo (ME) Dixon technique. METHODS: Twenty patients who volunteered to participate in this study were prospectively enrolled, including 4 female NAFLD patients and 1 normal control subjects; 12 males with NAFLD and 3 normal controls. Conventional liver MRI scan and ME sequence examination were performed, followed by single-body magnetic resonance spectroscopy (MRS). After the inspection, the data were processed. The Screening Dixon’s fat fraction (FF) value and the Histo sequence were obtained automatically. The FF values of the single-element MRS were measured manually. Three regions of interest (ROI) of the FF value. Finally, Spearman correlation analysis of each FF value was carried out. Results The FF values of Screening Dixon and ME Dixon measured in three ROI regions were highly correlated (r = 0.842, 0.959, 0.945, P <0.001). FF values measured in the three ROI regions of Screening Dixon and ME Dixon were highly positively correlated with FF values measured by Histo single-element MRS (r = 0.971,0.842,0.959,0.945, P <0.001 respectively) ). Conclusion The evaluation of liver fat content in NAFLD patients by 3.0T MRI ME Dixon imaging is feasible and highly correlated with the results of single-element MRS. The results for the diagnosis of NAFLD patients, follow-up and intervention monitoring have some clinical value.