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目的:探讨Ki-67和VEGF在胃肠间质瘤中的表达及与临床病理因素的关系,VEGF、微血管密度(MVD)和细胞增殖之间的相关性。方法:采用免疫组化S-P法检测44例胃肠间质瘤组织中Ki-67、VEGF表达及计数MVD值和Ki-67PI。结果:VEGF、Ki-67在GIST组织中阳性表达分别为77.3%、63.6%,VEGF、Ki-67表达在不同大小的肿块之间有统计学差异(P<0.01);MVD值和Ki-67PI在VEGF阳性和阴性组的比较有统计学差异(P<0.01);VEGF、MVD和Ki-67PI之间呈显著正相关(相关系数分别为0.26、0.44和0.84,P<0.01)。结论:VEGF促进GIST组织中的新生血管形成,为肿瘤组织提供了丰富的血液和营养,并使细胞增殖活性增强,促进肿瘤细胞的增殖、肿瘤的生长、发展和转移;Ki-67PI为GIST的预后判断提供了比较客观的依据。
Objective: To investigate the relationship between the expression of Ki-67 and VEGF in gastrointestinal stromal tumors and its clinicopathological factors, the correlation between VEGF, microvessel density (MVD) and cell proliferation. Methods: The expressions of Ki-67, VEGF and MVD and Ki-67PI in 44 cases of gastrointestinal stromal tumors were detected by immunohistochemical S-P method. Results: The positive rates of VEGF and Ki-67 in GIST tissues were 77.3% and 63.6%, respectively. The expressions of VEGF and Ki-67 in different sizes of tumors were significantly different (P <0.01). The MVD and Ki-67 There was significant difference between VEGF positive and negative groups (P <0.01). There was a significant positive correlation between VEGF, MVD and Ki-67PI (correlation coefficient was 0.26,0.44 and 0.84 respectively, P <0.01). Conclusion: VEGF can promote the formation of neovascularization in GIST tissue, provide abundant blood and nutrition for tumor tissue, enhance the cell proliferation activity, promote the proliferation of tumor cells, and the growth, development and metastasis of tumor. Ki-67PI is GIST Prognosis provides a more objective basis.