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以鲨鱼软骨为原料，经盐酸胍抽提、丙酮分级沉淀、超滤等步骤得到鲨鱼软骨抗肿瘤制剂（SCATP）。采用放射免疫分析方法测定其对荷瘤小鼠血浆6－Keto－PGF1α和TXB2水平的影响，整装细胞扫描电镜技术测定SCATP对Hela细胞骨架的影响，常规方法测定SCATP对小鼠脾脏和胸腺的影响及对荷瘤小鼠的抑癌效应。结果显示，（1）当剂量达20mg／kg时，SCATP能使荷瘤小鼠血浆6－Keto－PGF1α非常显著下降（P＜0．01），使TXB2水平显著下降（P＜0．05）；（2）SCATP能使Hela细胞骨架发生凝聚或固缩，并有明显的浓度依赖关系，提示SCATP能抑制肿瘤细胞的分裂增殖及运动迁移；（3）SCATP能刺激小鼠脾脏和胸腺，并显著抑制实验动物肿瘤的生长。
Shark cartilage as raw material, guanidine hydrochloride extraction, acetone precipitation, ultrafiltration and other steps to obtain shark cartilage anti-tumor agent (SCATP). The effects of SCATP on the 6-Keto-PGF1α and TXB2 levels in tumor-bearing mice were determined by radioimmunoassay. The effects of SCATP on the cytoskeleton of Hela cells were determined by scanning electron microscopy. The cytotoxicity of SCATP on the spleen and thymus Effect and tumor suppressor effect on tumor-bearing mice. The results showed that: (1) SCATP significantly decreased the plasma 6-Keto-PGF1α (P <0.01) and decreased the level of TXB2 significantly (P <0.05) at the dose of 20 mg / ; (2) SCATP can make the Hela cytoskeleton agglutinate or shrink, and have a significant concentration-dependent relationship, suggesting that SCATP can inhibit the proliferation and migration of tumor cells; (3) SCATP can stimulate the spleen and thymus and Significantly inhibited tumor growth in experimental animals.