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目的:探讨脚间区胆碱能神经元在家猫睡眠-觉醒周期中的作用。方法:选用家猫8只,于脚间区微量注射不同剂量的阿托品,记录睡眠-觉醒周期的变化。结果:给予三种剂量的阿托品后,快眼动睡眠从对照的67.4±2.7 min 分别减少到50.9±4.6,35.6±4.3和20.2±3.8min,慢波睡眠无明显变化,而觉醒时间由对照的43.9±3.4 min 分别增加为58.8±4.5,67.0±5.0和92.1±5.7 min。结论:上述结果提示脚间区胆碱能神经元通过释放乙酰胆碱影响睡眠-觉醒周期,在 REMS 睡眠的触发和维持中起重要作用。
Objective: To investigate the role of cholinergic neurons in the foot-cat sleep-wake cycle. Methods: Eight cats were selected and micro doses of atropine were injected into the interventricular area to record the changes of sleep-wake cycle. Results: After three doses of atropine, the REM sleep decreased from 67.4 ± 2.7 min to 50.9 ± 4.6, 35.6 ± 4.3 and 20.2 ± 3.8 min, respectively, while no significant changes were observed in slow-wave sleep. However, 43.9 ± 3.4 min increased to 58.8 ± 4.5, 67.0 ± 5.0 and 92.1 ± 5.7 min, respectively. CONCLUSION: The above results suggest that cholinergic neurons in the interventricular space play an important role in the triggering and maintenance of REMS sleep by releasing acetylcholine to affect the sleep-wake cycle.