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凋亡是细胞主动自我毁灭的一种正常生理现象,通过凋亡能消除自身不需要的、已严重损害的、或具有潜在危险性的细胞。若细胞凋亡过程发生紊乱,可能会导致细胞无限制增殖,从而导致病变,特别是肿瘤的发生。凋亡信号首先激活凋亡途径上游的Caspase启动分子,例如Caspase-8、Caspase-9等;继而通过一系列的级联反应激活下
Apoptosis is a normal physiological phenomenon that cells spontaneously destroy themselves. By apoptosis, they can eliminate their own unnecessary, severely damaged or potentially dangerous cells. If the process of apoptosis occurs disorder, may lead to unlimited cell proliferation, leading to lesions, especially tumors. The apoptotic signal first activates Caspase promoter molecules upstream of the apoptotic pathway, such as Caspase-8, Caspase-9 and the like; and then activates through a series of cascades