NF-rBp50、p53、Bcl-2在宫颈癌组织中的表达及其与人乳头瘤病毒感染的关系

• 作 者: 张婵 陈向敏 夏克栋 Haiyan Dong
• 机 构: The Biological Laboratory Education Center, Wenzhou Medical College, Wenzhou 325027, China;Departmen
• 出 处: 中德临床肿瘤学杂志（英文版）
• 发表日期: 2006年6期
• 关键词: cervical cancer NF-κBp50 p53 Bcl-2 HPV
• 基金项目: 浙江省温州市科技局资助项目

Objective: To explore the relationship between expressions of NF-κBp50, p53 and Bcl-2 in tissue of cervical cancer and human papillomavirus (HPV) infection. Methods: The expressions of NF-κBp50, p53 and Bcl-2 were detected using immuohistochemical staining in 46 specimens of cervical cancer and 26 specimens of normal cervical tissue. The infection of HPV DNA were determined by PCR. Results: The expressions of NF-κBp50, p53 and Bcl-2 in tissue of cervical cancer were significantly higher than that in normal cervical tissue (P＜0.01), and the expressions of NF-κBp50 and p53 or Bcl-2 were closely related (P＜0.05). The expression of NF-κBp50 in HPV DNA positive group was significantly higher than that in HPV negative group (P＜0.05), but there were no significantly differences in the expressions of p53 and Bcl-2 between HPV DNA positive group and HPV negative group (P＞0.05). Conclusion: The expressions of NF-κBp50, p53 and Bcl-2 were significantly correlated with cervical carcinogenesis. NF-κBp50 may be activated by HPV infection.