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特发性精子减少症(Idiopahic Oligospermia,IO)是由于睾丸功能紊乱所致的男性不育症,其中包括精子计数低,活动率低或/和精子形态异常等。临床上较多见,约占全部男性不育症的70～80％。目前,由于对生精功能障碍的机理不甚了解,所以治疗上尚无特效方法。本文就近十年来国内外对IO治疗的研究进展作一综述。一、雄激素反跳疗法(Androgen Rebound Therapy,ART) 一般认为,补充外源性雄激素对因内源性睾酮缺乏所致的精子减少似乎无效,但其反跳疗法可明显增加精子的发生,这一作用是Heller等首先发现的。随后,Charny利用ART治疗男性不育症取得成功。因为,大剂量雄激素可抑制垂体促性腺激素(Gona
Idiopahic Oligospermia (IO) is male infertility due to testicular dysfunction, including low sperm count, low activity rate, and / or abnormal sperm morphology. Clinically more common, accounting for about 70 to 80% of all male infertility. At present, due to lack of understanding of the mechanism of spermatogenic dysfunction, so there is no effective method of treatment. This article reviews the research progress of IO therapy at home and abroad in recent ten years. Androgen Rebound Therapy (ART) It is generally believed that supplementing exogenous androgen does not appear to be effective in reducing sperm loss due to endogenous testosterone deficiency, but its rebound therapy can significantly increase the incidence of sperm, This effect was first discovered by Heller et al. Subsequently, Charny ART successful treatment of male infertility. Because high-dose androgen suppresses pituitary gonadotropin (Gona