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免疫组化证实,转化生长因子-α(TGF-α)存在于人食管粘膜上皮生发层内。食管腔内释出的TGF-α可能起粘膜保护作用。胃食管返流物中酸及胃蛋白酶是导致返流性食管炎(RE)形成的主要攻击性因子,本研究旨在观察酸及胃蛋白酶对无症状志愿者及RE患者食管腔内TGF-α
Immunohistochemistry confirmed that transforming growth factor-α (TGF-α) exists in the human esophageal epithelial germinal layer. TGF-α released from the esophageal lumen may play a role in mucosal protection. In the gastroesophageal reflux disease, acid and pepsin are the main aggressive factors that lead to the formation of reflux esophagitis (RE). This study aimed to observe the effect of acid and pepsin on esophageal cavity TGF- α