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目的通过对过敏性紫癜患儿血清中免疫球蛋白、T淋巴细胞亚群的变化,进一步了解小儿过敏性紫癜的发病机制,以更好地治疗该征。方法过敏性紫癜患儿36例,男19例,女17例;平均年龄(5.88±1.46)岁。对照组33例,男18例,女15例;平均年龄(5.98±1.18)岁。免疫球蛋白应用免疫散射比浊法检测,应用流式细胞法检测T淋巴细胞亚群。结果过敏性紫癜患儿血清中IgA升高,与对照组相比,差异有统计学意义(P<0.05)。过敏性紫癜患儿血清中T淋巴细胞亚群均较对照组降低,以CD8降低最明显,有统计学意义(P<0.01)。结论过敏性紫癜患儿存在体液免疫、细胞免疫紊乱,对过敏性紫癜患儿检测免疫功能有一定的临床意义。
Objective To further understand the pathogenesis of Henoch-Schonlein purpura in children with Henoch-Schonlein purpura to better treat this syndrome by analyzing the changes of serum immunoglobulin and T lymphocyte subsets in children with Henoch-Schonlein purpura. Methods 36 children with Henoch-Schonlein purpura, 19 males and 17 females, with an average age of 5.88 ± 1.46 years old. Control group, 33 cases, 18 males and 15 females; mean age (5.98 ± 1.18) years. Immunoglobulins were detected by immune nephelometry. T lymphocyte subsets were detected by flow cytometry. Results Serum IgA levels in children with Henoch-Schonlein purpura were significantly higher than those in control group (P <0.05). Children with Henoch-Schonlein purpura serum T-lymphocyte subsets were lower than the control group, the most obvious reduction of CD8, with statistical significance (P <0.01). Conclusion There are humoral and cellular immune disorders in children with Henoch-Schonlein purpura, which may be of clinical significance for the detection of immune function in children with Henoch-Schonlein purpura.