论文部分内容阅读
目的探讨比较口服地屈孕酮与注射黄体酮治疗先兆流产的临床疗效。方法选取2015年2月至2016年12月河源市妇幼保健院收治的先兆流产患者80例为研究对象,按照随机数字表法分为研究组与对照组,每组40例,两组患者治疗期间均严格卧床休息,绝对禁止性生活,并规律口服叶酸,研究组患者口服地屈孕酮片,对照组患者使用黄体酮注射液,比较两组患者的整体保胎情况,比较两组患者孕6周、孕8周及孕10周体内孕酮水平变化,并观察两组患者治疗期间出现的并发症情况。结果研究组40例患者中,保胎成功39例,保胎成功率为97.5%;对照组40例患者中,保胎成功30例,保胎成功率为75.0%。两组保胎成功率比较,差异有统计学意义(P<0.05)。研究组患者孕6周、孕8周及孕10周的体内孕酮水平均显著高于对照组,差异均有统计学意义(均P<0.05)。研究组患者恶心呕吐、乳房胀痛及头晕的总不良反应发生率均显著低于对照组,差异有统计学意义(P<0.05)。结论与使用黄体酮相比,使用地屈孕酮治疗先兆流产能保证保胎成功率,提高机体孕酮水平,且药物不良反应少,安全性高。
Objective To investigate the clinical efficacy of oral progesterone and progesterone injection in the treatment of threatened abortion. Methods Eighty cases of threatened abortion admitted to Heyuan MCH from February 2015 to December 2016 were selected as research objects and divided into study group and control group according to random number table method, with 40 cases in each group. During treatment period Were strictly bed rest, absolute prohibition of sex life, and regular oral folic acid, study patients oral delivery of progesterone tablets, the control group of patients with progesterone injection, the two groups of patients compared the overall miscarriage situation, compared two groups of pregnant women 6 Week, 8 weeks pregnant and 10 weeks pregnant body progesterone level changes, and observed two groups of patients during the treatment of complications. Results Among the 40 patients in study group, 39 cases of miscarriage were successful and the miscarriage success rate was 97.5%. Among the 40 cases of control group, the miscarriage was successful in 30 cases and the miscarriage success rate was 75.0%. Two groups of miscarriage success rate, the difference was statistically significant (P <0.05). The progesterone levels in the study group were significantly higher than those in the control group at 6 weeks of gestation, 8 weeks of gestation and 10 weeks of gestation. The differences were statistically significant (all P <0.05). The incidence of adverse reactions in study group was significantly lower than that in control group (P <0.05). Conclusion Compared with the use of progesterone, the use of dydrogesterone in the treatment of threatened abortion can guarantee the success rate of miscarriage and improve the level of progesterone in the body with less adverse drug reactions and high safety.