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目的对克霉唑治疗妊娠合并假丝酵母菌感染(VVC)的疗效进行分析,探寻妊娠VVC的敏感药物。方法筛查600例妊娠合并VVC感染的患者随机分为克霉唑栓组200例、制霉菌素栓组200例、咪康唑栓组200例。对三组患者的治疗效果进行统计分析,比较不同药物对妊娠合并假丝酵母菌感染的疗效。结果克霉唑栓组、制霉菌素栓组、咪康唑栓组对妊娠合并假丝酵母菌感染的总有效率分别为92.0%、79.0%、76.0%,克霉唑组有效率高于制霉菌素组及咪康唑组(P均<0.05)。不良反应发生率,克霉唑栓组为1.0%,制霉菌素组为3.5%,咪康唑组为3.0%,三组间不良反应发生率比较差异无统计学意义(P均>0.05)。结论克霉唑阴道栓治疗妊娠合并假丝酵母菌感染疗效可靠,不良反应少。
Objective To analyze the curative effect of clotrimazole in the treatment of pregnancy complicated with Candida infection (VVC) and explore the sensitive drugs for pregnancy VVC. Methods Six hundred and sixty pregnant women with VVC infection during pregnancy were randomly divided into clotrimazole suppository group (n = 200), nystatin suppository group (n = 200) and miconazole suppository group (n = 200). The treatment effect of three groups of patients were statistically analyzed to compare the efficacy of different drugs on pregnancy complicated with Candida infection. Results The total effective rates of clotrimazole suppository, nystatin suppository and miconazole suppository group were 92.0%, 79.0%, 76.0%, respectively. The effective rate of clotrimazole group was higher than that of nystatin Group and miconazole group (all P <0.05). The incidence of adverse reactions was 1.0% in the clotrimazole suppository group, 3.5% in the nystatin group and 3.0% in the miconazole group. There was no significant difference in the incidence of adverse reactions among the three groups (P> 0.05). Conclusion Clotrimazole vaginal suppository treatment of pregnancy with Candida infection is reliable and has few adverse reactions.