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应用OKT系列单克隆抗体及原子吸收光谱法检测健康老年人及老年慢支患者外周血淋巴细胞亚群及血清铜值的变化。结果表明健康老年组T(OKT_3~+)及T_H(OKT_4~+)细胞显著降低,Ts(OKT_8~+)细胞显著增高,T_H/Ts比值显著降低,老年慢支组此种变化更为明显。健康老年组血清铜值显著高于青中年组,慢支组血清铜值显著高于健康老年组(均P<0.01)。相关分析表明,健康老年人血清铜值与OKT_3~+、OKT_4~+、OKT_8+、B细胞百分率,PHA皮试及OT皮试反应强度无显著相关。
OKT series of monoclonal antibodies and atomic absorption spectrometry were used to detect peripheral blood lymphocyte subsets and serum copper values in healthy elderly and elderly patients with chronic bronchitis. The results showed that the OKT_3 ~ + and T_H OKT_4 ~ + cells in the healthy elderly group were significantly decreased, the OKT_8 ~ + cells were significantly increased, the T_H / Ts ratio was significantly decreased, and the changes in the elderly chronic bronchitis group were more obvious. The serum copper value of healthy elderly group was significantly higher than that of young middle-aged group, and the serum copper value of chronic bronchitis group was significantly higher than that of healthy elderly group (all P <0.01). Correlation analysis showed that there was no significant correlation between serum copper values and OKT_3 ~ +, OKT_4 ~ +, OKT_8 +, B cell percentage, PHA skin test and OT skin test reaction intensity.