论文部分内容阅读
观察排卵期服用300mg米非司酮进行房事后避孕的效果和对月经的影响,在对照周期、用药周期和恢复周期,血浆雌二醇(E_2)、孕酮(P)和黄体生成素(LH)浓度的变化,以及米非司酮对分泌期子宫内膜的影响。接受85名育龄妇女为受试者。60例主要观察避孕效果和月经恢复情况,另25例在三个不同周期中,定期取静脉血测三种激素水平,并在服米非司酮后第4～5天,取子宫内膜进行形态学检查。共观察129个服药周期,妊娠率为0.78％。其中18个周期出现服米非司酮后阴道少量出血,但未干扰正常月经规律,无明显副反应发生。在用药周期和恢复周期中,血浆E_2、P和LH的水平未受影响。形态学检查显示子宫内膜发育延迟。本研究联合使用几种监测排卵方法,提示在排卵后72小时内服300mg米非司酮安全、有效,在分泌早期服用米非司酮可以考虑作为一月一次的避孕方法。
Observe the effect of ovulation taking 300mg mifepristone on post-operative contraception and its effect on menstruation during the control period, medication period and recovery period, plasma estradiol (E2), progesterone (P) and luteinizing hormone ) Concentration changes, as well as the impact of mifepristone on endometrial secretion. 85 women of childbearing age were accepted as subjects. 60 cases of primary observation of contraceptive effectiveness and menstrual recovery, and the other 25 cases in three different cycles, regular venous blood test three hormone levels, and taking mifepristone 4 to 5 days, take the endometrium Morphological examination. A total of 129 medication cycles were observed with a pregnancy rate of 0.78%. Of which 18 cycles of taking mifepristone vaginal bleeding, but did not interfere with normal menstrual regularity, no obvious side effects. Plasma levels of E 2, P, and LH were unaffected during the medication and recovery cycles. Morphological examination showed delayed endometrial development. This study combined the use of several monitoring methods of ovulation, suggesting that within 300 hours after ovulation 300mg mifepristone safe and effective in the early secretion of mifepristone can be considered as a contraceptive method once a month.