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目的观察茵栀黄口服液联合间歇蓝光照射治疗新生儿病理性黄疸的疗效。方法将96例新生儿病理性黄疸患儿随机分为对照组和治疗组,各48例。对照组给予输液、静脉输注白蛋白、静脉注射维生素C、口服维生素B2等常规治疗,并进行蓝光照射,4 h/次,间歇2 h,4次/d,治疗组在对照组治疗方法的基础上口服茵栀黄口服液,5 m L/次,2次/d。治疗7 d后统计2组患儿的临床疗效。结果对照组总有效率为89.6%,治疗组为97.9%,经统计学分析,差异有统计意义(P<0.05)。治疗后第1,3,7天,2组胆红素水平均逐渐下降,与同组治疗前比较,差异有统计意义(P<0.05);且治疗组胆红素水平下降幅度大于对照组,经统计学分析,差异有统计意义(P<0.05)。治疗组患儿的胆红素水平恢复至正常时间及住院时间明显短于对照组,经统计学分析,差异有统计意义(P<0.05)。结论茵栀黄口服液联合间歇蓝光照射可明显缩短新生儿病理性黄疸的治疗时间,提高临床疗效。
Objective To observe the curative effect of Yinzhihuang oral liquid and intermittent blue light irradiation on neonatal pathological jaundice. Methods 96 cases of neonatal pathological jaundice were randomly divided into control group and treatment group, each 48 cases. Control group was given infusion, intravenous infusion of albumin, intravenous vitamin C, oral vitamin B2 and other conventional treatment, and blue light irradiation, 4 h / time, intermittent 2 h, 4 times / d, the treatment group in the control group On the basis of oral Yin Zhihuang oral solution, 5 m L / time, 2 times / d. After 7 days of treatment, the clinical efficacy of two groups of children was statistically analyzed. Results The total effective rate was 89.6% in the control group and 97.9% in the treatment group. The difference was statistically significant (P <0.05). The levels of bilirubin in both groups decreased gradually on the 1st, 3rd, 7th day after treatment, with statistical significance (P <0.05) compared with those before treatment in the same group. The decrease of bilirubin level in the treatment group was larger than that in the control group, The statistical analysis, the difference was statistically significant (P <0.05). The bilirubin level of the treatment group returned to normal time and hospitalization time was significantly shorter than the control group, the statistical analysis, the difference was statistically significant (P <0.05). Conclusion Yinzhihuang oral intermittent blue light irradiation can significantly shorten the treatment of neonatal pathological jaundice and improve clinical efficacy.