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本文采用ＬＤ＿（７５）的Ｏ＿（１１１）Ｂ＿４大肠杆菌内毒素建立小鼠实验性内毒素血症模型，观察肝素对内毒素血症的保护作用。结果，生理盐水对照组存活率为３３．３３％，肝素对小鼠内毒素血症有显著保护作用，５．５Ｕ／２０ｇ小鼠组存活率６３．６４％（Ｐ＜０．０５）；３．０Ｕ／２０ｇ小鼠组为７９．１７％（Ｐ＜０．００５）；１．５Ｕ／２０ｇ小鼠组７５．００％（Ｐ＜０．００５）。肝素注射时间对小鼠内毒素血症保护作用依次为肝素与内毒素同时注射（７９．１７％）；内毒素注入后３０ｍｉｎ（７５．００％）；内毒素注入前３０ｍｉｎ（７０．８３％）和注入前６０ｍｉｎ（５８．３３％）。注射途径依次为静脉注射（７９．１７％）、皮下注射（７７．２７％）、腹腔注射（７５．００％）、肌肉注射（７０．８３％），统计学上无明显差异。表明中小剂量肝素对小鼠内毒素血症有明显保护作用，早期使用、静脉和皮下注射疗效明显。
In this paper, LD_ (75) O_ (111) B_4 E. coli endotoxin was used to establish mouse experimental endotoxemia model to observe the protective effects of heparin on endotoxemia. Results: The survival rate of control group was 33.33%. Heparin had a significant protective effect on endotoxemia in mice. The survival rate of mice in 5.5U / 20g group was 63.64% (P <0.05). 3 79.17% (P <0.005) in the group of 0U / 20g mice and 75.00% (P <0.005) in 1.5U / 20g mice group. The protective effect of heparin injection on endotoxemia in mice was followed by simultaneous heparin and endotoxin injection (79.17%); 30 min (75.00%) after endotoxin injection; 30 min (70.83%) before endotoxin injection And 60min before injection (58.33%). The injection route was followed by intravenous injection (79.17%), subcutaneous injection (77.27%), intraperitoneal injection (75.00%) and intramuscular injection (70.83%). There was no statistically significant difference. Small and medium-dose heparin shows that endotoxemia in mice has a significant protective effect, early use, intravenous and subcutaneous injection of significant effect.