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目的了解儿童不同剂次乙肝疫苗加强免疫的效果。方法按学号系统等距随机抽取陆良县芳华镇小学生337人,要求1岁内接受过基础接种但未加强免疫,且接种前乙肝两对半5项均为阴性。其中306人加强免疫1剂次为1剂次组,31人加强免疫3剂次(0,1,6)程序为3剂次组,对两组学生接种后1个月乙肝表面抗体抗-HBs,进行检测分析。结果 337名小学生年龄6~14岁,1剂次与3剂次组加强免疫后抗-HBs阳性率分别为94.12%和100.00%,两组差异无统计学意义(P>0.05);两组学生抗-HBs阳性率在不同年龄、性别和地区间差异均无统计学意义(P>0.05)。结论 6~14岁儿童加强免疫1剂次或3剂次乙肝疫苗后均能产生较高的抗-HBs阳性率;但3剂次是否优于1剂次,需扩大样本进一步研究。
Objective To understand the effect of different doses of hepatitis B vaccine on boosting immunity in children. Methods A total of 337 primary school students in Fanghua Town of Luliang County were randomly selected according to the system of student numbers. Five years of pre-vaccination hepatitis B hepatitis B was negative. Among them, 306 were boosted 1 dose for 1 dose group and 31 were boosted 3 doses (0, 1, 6) for 3 dose group. One month after vaccination, HBsAg anti-HBs , For testing and analysis. Results The positive rates of anti-HBs in 337 primary school children aged 6-14 years, 1 dose and 3 doses were 94.12% and 100.00%, respectively. There was no significant difference between the two groups (P> 0.05) The positive rate of anti-HBs in different age, gender and regional differences were not statistically significant (P> 0.05). Conclusions The positive rate of anti-HBs in children aged 6-14 years after boosting with 1 or 3 doses of hepatitis B vaccine is high. However, whether the 3 doses are better than 1 dose should be further studied.