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孕妇初次感染人细小病毒B19(以下简称B19)会导致非免疫性胎儿水肿及宫内胎儿死亡。本研究目的主要是用血清学和病毒学方法更好地确定孕妇初次感染B19后的宫内传播率,明确可能影响宫内传播的因素。受试者是在两个医疗中心经检测血清B19 IgM确诊为初次感染B19的孕妇,检样为分娩时的母亲及婴儿脐带血,还收集了13个婴儿分娩后1年间随访的血清、尿样及唾液。
The first infection of pregnant women with human parvovirus B19 (hereinafter referred to as B19) will lead to non-immune fetal edema and intrauterine fetal death. The main purpose of this study is to determine the intrauterine transmission rate of pregnant women after initial infection with B19 by serological and virological methods and to identify the factors that may affect intrauterine transmission. Subjects were pregnant women who had been diagnosed with primary B19 IgM by seronegative B19 IgM at two medical centers and were sampled at the time of delivery for both mother and infant cord blood and for 13 babies followed up for 1 year after delivery And saliva.