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目的探讨血清胱抑素C(Cys C)、β_2微球蛋白(β_2-MG)对妊娠糖尿病(GDM)患者肾损害的早期诊断价值。方法分别检测妊娠期糖尿病孕妇及健康对照组孕妇血清Cys C、β2-MG、尿素氮(BUN)、肌酐(Scr)、尿酸(UA)水平。结果 GDM组孕妇的Cys C、β_2-MG水平显著高于对照组(P<0.01),两组BUN Scr、UA比较无统计学意义。结论 Cys C、β_2-MG对更好的早期诊断GDM肾病具有重要意义。
Objective To investigate the early diagnosis value of serum cystatin C (Cys C) and β 2 microglobulin (β 2-MG) on renal damage in patients with gestational diabetes mellitus (GDM). Methods Serum levels of Cys C, β2-MG, BUN, Scr and UA in pregnant women with gestational diabetes mellitus and healthy controls were measured. Results The levels of Cys C and β 2-MG in pregnant women in GDM group were significantly higher than those in control group (P <0.01). There was no significant difference in BUN Scr and UA between the two groups. Conclusion Cys C, β 2-MG is of great importance for early diagnosis of GDM nephropathy.