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目的研究巴曲酶治疗时间对急性脑梗死患者脑血管储备功能的影响。方法 160例急性脑梗死患者,根据患者的发病时间情况分成对照组(70例)与观察组(90例)。对照组患者随机分成对照A组和对照B组,每组35例;观察组患者随机的分成观察A组和观察B组,每组45例。对照A组中的患者是发病12 h以内进行急性脑梗死常规治疗的患者,观察A组是发病12 h以内接受常规治疗联合巴曲酶治疗的患者;对照B组中患者为发病12~24 h的接受常规治疗,观察B组为发病12~24 h接受常规治疗联合巴曲酶治疗的患者。四组患者在治疗结束后,对患者脑血管储备功能进行分析比较。结果观察组与对照组的脑血管反应性(CVR)和大脑中动脉平均血流流速增加值(MFV1-MFV0)在治疗后较治疗前有明显的升高,动脉指数(PI)治疗后较治疗前有明显的降低。治疗后,观察A组和观察B组的CVR、MFV1-MFV0和PI改善程度显著高于对照A组和对照B组(P<0.05)。观察A组的CVR(42.15±5.35)%、MFV1-MFV0(32.54±10.45)cm/s和PI(0.64±0.08)改善程度显著高于观察B组(32.56±6.43)%、(26.32±11.47)cm/s、(0.79±0.07)(P<0.05)。结论巴曲酶在急性脑梗死的治疗中疗效显著,在发病较短时间12 h以内治疗可显著改善急性脑梗死患者的脑血管储备功能。
Objective To study the effect of batroxobin on cerebral vascular reserve in patients with acute cerebral infarction. Methods 160 patients with acute cerebral infarction were divided into control group (n = 70) and observation group (n = 90) according to the onset time of patients. Patients in the control group were randomly divided into control group A and control group B, 35 cases in each group. Patients in observation group were randomly divided into observation group A and observation group B, with 45 cases in each group. Patients in control group A were patients who were treated routinely with acute cerebral infarction within 12 hours of onset. Patients in group A were treated with conventional therapy and batroxobin within 12 hours after onset of disease. Patients in control group B were patients with onset of 12-24 hours The patients in group B were treated with routine therapy combined with batroxobin for 12-24 hours. After treatment, the four groups of patients were analyzed and compared with the cerebrovascular reserve function. Results The CVR and MFV-MFV of the observation group and the control group were significantly increased after treatment compared with those before treatment, while those after arterial index (PI) treatment were higher than those after treatment Significantly reduced before. After treatment, the improvement of CVR, MFV1-MFV0 and PI in observation group A and observation group B were significantly higher than those in control A group and control group B (P <0.05). The improvement of CVR (42.15 ± 5.35)%, MFV1-MFV0 (32.54 ± 10.45) cm / s and PI (0.64 ± 0.08) in observation group A was significantly higher than that in observation group B (32.56 ± 6.43)%, (26.32 ± 11.47) cm / s, (0.79 ± 0.07) (P <0.05). Conclusion Batroxobin is effective in the treatment of acute cerebral infarction. Treatment within a short time of 12 h can significantly improve the cerebral vascular reserve function in patients with acute cerebral infarction.