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目的:探讨急性中心性浆液性脉络膜视网膜病变(CSC)患者视网膜浅层毛细血管丛(SCP)/深层毛细血管丛(DCP)毛细血管血流密度及黄斑无血管区(FAZ)变化特征。方法:回顾性分析晋城煤业集团总医院2017年1月至2019年10月收治的急性CSC患者45例的临床资料，其中患眼、健眼各45眼分别设为患眼组、健眼组，选取体检健康人群30例30只眼为对照组。比较各组FAZ、血流密度、黄斑中心凹视网膜厚度(CMT)及脉络膜厚度(SFCT)，同时分析毛细血管血流增强形态。结果:三组SCP中FAZ水平差异无统计学意义(n P>0.05)；患眼组DCP中FAZ为(0.81±0.19)mmn 2，均显著高于健眼组的(0.43±0.12)mmn 2、对照组的(0.38±0.08)mmn 2(n t＝3.17、3.22，均n P<0.05)；患眼组、健眼组SCP/DCP中血流密度显著均低于对照组(n t＝2.69、3.01，均n P<0.05)。患眼组CMT、SFCT分别为(427.43±35.66)μm、(359.43±32.95)μm，均显著高于健眼组的(276.35±17.02)μm、(260.38±25.66)μm和对照组的(285.69±11.47)μm、(235.76±20.50)μm(n t＝8.17、9.89，10.26、15.92，均n P0.05)；健眼组SFCT显著高于对照组(n t＝4.39，n P0.05). The FAZ in DCP of the lesion eye group[(0.81±0.19)mmn 2] was significantly higher than that in the healthy eye group [(0.43±0.12)mmn 2] and the control group [(0.38±0.08)mmn 2](n t=3.17, 3.22, all n P<0.05). The blood flow density in the SCP/DCP of the lesion eye group and healthy eye group were significantly lower than those in the control group(n t=2.69, 3.01, all n P<0.05). The levels of CMT and SFCT in the lesion eye group [(427.43±35.66)μm and (359.43±32.95)μm] were significantly higher than those in the healthy eye group [(276.35±17.02)μm and (260.38±25.66)μm] and the control group [(285.69±11.47)μm and (235.76±20.50)μm] (n t=8.17, 9.89; 10.26, 15.92; all n P0.05). The level of SFCT of the healthy eye group was significantly higher than that in the healthy eye group and control group(n t=4.39, n P<0.05). The results of optical coherence tomography showed that the local enhancement of capillary blood flow was seen in 23 eyes, and the diffuse enhancement of blood flow was seen in 22 eyes in the affected eye group, and there was subretinal effusion at the same time.In the healthy eye group, the signal changes of capillary strength and intensity were seen.In the control group, there was no significant change.n Conclusion:The results of OCTA showed that in lesion eye group, local enhancement of capillary blood flow was seen in 23 eyes and diffuse enhancement of blood flow was seen in 22 eyes, and subretinal effusion was all found.In healthy eye group, even strong and weak signal changes of capillary were seen, while there were no above changes in control group.