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胰头部肿块型慢性胰腺炎与胰头癌难以鉴别,虽然其属于良性病变,但有一定的恶变率。慢性胰腺炎基础上的组织增生、萎缩以及癌变过程中,癌基因激活和抑癌基因失活可以导致胰腺癌的发生。影像医学的发展为两者的鉴别诊断提供了直观的影像学证据,但是,目前的诊断方法包括CT、MRI、ERCP、EUS(FNA)和PET-CT都存有一定的不足,导致诊断困难。因此,手术是最终诊断胰腺癌和肿块型慢性胰腺炎的惟一手段。
Pancreatic head mass chronic pancreatitis and pancreatic cancer is difficult to identify, although it is a benign lesion, but there is a certain rate of malignancy. Chronic pancreatitis based on tissue proliferation, atrophy and carcinogenesis, oncogene activation and tumor suppressor gene inactivation can lead to the occurrence of pancreatic cancer. However, the current diagnostic methods including CT, MRI, ERCP, EUS (FNA) and PET-CT all have certain deficiencies, leading to difficulties in diagnosis. Therefore, surgery is the only means for the final diagnosis of pancreatic cancer and mass chronic pancreatitis.