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喹诺酮类是由一大类对肠杆菌科,其它革兰氏阴性菌和葡萄球菌具有显著活性的抗微生物药物组成,它们对链球菌和肠球菌示中等活性。喹诺酮类口服后显示的生物利用度高,组织分布也广,不过它们的蛋白结合率低或者可忽略。不管这些确定特性,一种特有的禁忌症,可能会产生对成长中个体关节软骨的作用,仍然限制了它们在成年患者中的使用。1972年 Bailey 等报道萘啶酸中,首次指出喹诺酮会引起关节痛的可能,继后对各类动物和各种喹诺酮衍生物,诸如萘啶酸、吡
Quinolones are composed of a broad class of antimicrobial drugs that have significant activity against Enterobacteriaceae, other Gram-negative bacteria, and Staphylococcus, which show moderate activity against streptococci and enterococci. Quinolones show high bioavailability and tissue distribution after oral administration, but their protein binding rate is low or negligible. Regardless of these defining characteristics, a characteristic contraindication that may have an effect on growing individual articular cartilage still limits their use in adult patients. In 1972, Bailey and other reports of nalidixic acid, for the first time that quinolones may cause arthralgia, followed by a variety of animals and a variety of quinolone derivatives, such as nalidixic acid, pyridine