Experimental Study on Inhibitory Effect of Niacinamide on Tumor Necrosis Factor-alpha-induced Matrix

• 作 者: 徐润冰 邵增务 熊蠡茗
• 机 构: DepartmentofOrthopedicSurgery,DepartmentofOrthopedicSurgery
• 出 处: 华中科技大学学报：医学英德文版
• 发表日期: 2008年5期
• 关键词: 肿瘤坏死因子 烟酰胺 纤维组织 基质降解 半胱氨酸天冬氨酸特异性蛋白酶 免疫组织化学染色 抑制作用 实验研究 intervertebral disc degen

The inhibitory effect of niacinamide on tumor necrosis factor-α (TNF-α) induced annulus fibrous (AF) degradation was assessed, and the mechanism of the inhibition was investigated. Chiba's intervertebral disc (IVD) culture model was established. Forty