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结扎家兔冠脉左室支10min、松结重灌流60min时,其血压(Bp)、左心室收缩压(LVSP)恢复程度与对照组水平相比仅差3～4%,而其心肌收缩成分实际最大缩短速度(dp/dt/p_(max))、心肌收缩成分最大缩短速度(V_(max))却差13.9%。硝酸甘油(NTG)静脉输入可使家兔缺血重灌注后心肌的dP/dt/p_(max)、V_(max)与Bp、LVSP快速恢复接近正常。前两项指标与对照组同类指标水平只差5.5%(P>0.05),与不给NTG的心肌缺血组相比,有显著性差异(P<0.05)。对正常家兔静输NTG降低Bp、LVSP、左心室舒张末压(LVEDP)(P<0.05),不改变dp/dt/p_(max)、V_(max)和心率。结果表明NTG促使缺血心肌收缩性更快的恢复。
Ligation of rabbit coronary artery left ventricular branch 10min, pine knot reperfusion 60min, the blood pressure (Bp), left ventricular systolic pressure (LVSP) recovery compared with the level of the control group only 3 to 4%, while the myocardial contraction component The actual maximum shortening speed (dp / dt / p_ (max)), myocardial contraction component maximum shortening speed (V_ (max)) but poor 13.9%. Nitroglycerin (NTG) intravenous infusion can make the myocardial dP / dt / p max, V max and Bp, LVSP recover quickly after ischemia and reperfusion in rabbits. The first two indexes were only 5.5% lower than those of the control group (P> 0.05), but there was a significant difference (P <0.05) compared with the myocardial ischemia group without NTG. NTG administration in normal rabbits decreased Bp, LVSP and LVEDP (P <0.05), but did not change dp / dt / p max, V max and heart rate. The results show that NTG promotes a more rapid recovery of ischemic myocardial contractility.