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目的:研究龙寿丹对急性脑梗塞(ACI)患者血清肿瘤坏死因子(TNF)及循环内皮细胞(CEC)含量的影响,进一步探讨龙寿丹治疗脑梗塞有效的作用机制,为龙寿丹治疗脑梗塞的临床应用提供理论依据。方法:采用放射免疫分析法检测40例ACI患者服用龙寿丹前后血清TNFα和CEC的含量,并与20例未服用龙寿丹的ACI患者及20名健康人作对照。结果:(1)ACI患者血清TNFα和CEC含量明显高于健康组,且增高的程度与梗塞灶大小密切相关,梗塞灶越大,其含量越高。(2)ACI患者血清TNFα与CEC呈正相关(r=068,P<001)。(3)4周后两组ACI患者血清TNFα及CEC含量均降低,但治疗组降低更明显,与对照组比较具有显著性差异(P<001)。结论:龙寿丹降低了ACI患者血清中增高的TNFα及CEC,减轻了脑血管内皮细胞的损害,对脑血管内皮细胞及缺血神经元具有保护作用。
Objective: To study the effect of Long Shoudan on serum tumor necrosis factor (TNF) and circulating endothelial cell (CEC) levels in patients with acute cerebral infarction (ACI) and further explore the effective mechanism of Long Shoudan treatment of cerebral infarction. The clinical application of cerebral infarction provides a theoretical basis. METHODS: Radioimmunoassay was used to detect the serum levels of TNFα and CEC in 40 patients with ACI before and after taking Longshoudan, and compared with 20 patients with ACI who did not take Longshoudan and 20 healthy subjects. Results: (1) Serum levels of TNFα and CEC in patients with ACI were significantly higher than those in the healthy group, and the degree of increase was closely related to the size of infarct size. The larger the infarct size, the higher the content. (2) There was a positive correlation between serum TNFα and CEC in patients with ACI (r=068, P<001). (3) After 4 weeks, the levels of serum TNFα and CEC in both groups of ACI patients decreased, but the treatment group decreased more significantly, and there was a significant difference compared with the control group (P < 001). Conclusion: Longshoudan reduced the serum levels of TNFα and CEC in patients with ACI, reduced the damage of cerebral vascular endothelial cells, and protected the cerebral vascular endothelial cells and ischemic neurons.