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目的观察长期口服小剂量罗红霉素对稳定期慢性阻塞性肺疾病(COPD)急性加重频率的影响。方法前瞻性、随机临床病例对照研究。稳定期COPD患者80例,分别给予常规治疗及常规治疗加罗红霉素150mg,po,qd,疗程6个月。记录研究期间患者发生COPD急性加重的频率和程度。结果73例患者完成研究,共发生COPD急性加重74人次,治疗组21人次,对照组53人次,P<0.01。结论COPD稳定期的患者长期口服小剂量罗红霉素可以减小急性加重频率。
Objective To observe the effect of long-term oral low dose roxithromycin on the acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods Prospective, randomized clinical case-control study. 80 patients with stable COPD were given conventional treatment and routine treatment plus roxithromycin 150mg, po, qd, course of treatment for 6 months. The frequency and extent of COPD exacerbations were recorded during the study. Results 73 patients completed the study, a total of 74 patients with acute exacerbation of COPD, 21 patients in the treatment group, 53 patients in the control group, P <0.01. Conclusion Long-term oral administration of roxithromycin in patients with stable COPD can reduce the frequency of acute exacerbations.