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目的 :当糖尿病 ( DM)肾功能早期损害时 ,检测血清透明质酸 ( HA)水平变化的意义及 HA水平与肾功能损害程度的价值。方法 :应用放射免疫法直接检测病人血清中HA水平。结果 :病人各组血清 HA水平明显或数倍高于正常对照组。 HA升高明显早于血中尿素 ( Urea)、肌酐 ( Cr)和尿中蛋白 ,并密切相关 ( r=0 .76、0 .70、0 .95 )。结论 :检测血中HA水平是用来判断 DM肾功能早期受损的敏感指标或肾小球纤维化程度的有用指标 ,同时也可对糖尿病肾损害的发生发展及早期诊断具有重要价值
OBJECTIVE: To detect the change of serum hyaluronic acid (HA) level and the value of HA level and the extent of renal dysfunction in the early stage of diabetic renal damage. Methods: The level of HA in serum of patients was detected directly by radioimmunoassay. Results: The level of serum HA in each group of patients was obviously or several times higher than that of the normal control group. HA increased significantly earlier than the blood Urea, creatinine (Cr) and urinary protein, and closely related (r = 0.76,0. 70,0. 95). Conclusion: Detecting HA level in blood is a useful index to judge the sensitivity of DM early renal damage or the degree of glomerular fibrosis. It can also be of great value to the development and early diagnosis of diabetic nephropathy