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目的探讨兰州市2010~2015年产前筛查、诊断与出生缺陷发生的关系。方法收集2009年10月1日-2015年9月30日兰州市8个县区以及兰州新区上报的产前筛查、诊断情况年报表,出生缺陷儿报告卡,围产儿数季报表,采用Epi Data3.0软件建立数据库,并且SPSS 16.0软件进行统计整理分析。结果 2015年兰州市产前筛查人数、阳性率和产前诊断确诊率较2010年分别增加了10 970例、45.44%和31.94%;随着产前筛查人数增加、阳性率及产前诊断确诊率的上升,出生缺陷发生率、引产出生缺陷率以及7 d内出生缺陷儿死亡率也明显增加,较2010年分别上升了48.32%、57.02%和57.27%。结论产前筛查与诊断对防止出生缺陷儿出生具有至关重要的作用,是目前和将来降低出生缺陷发生率的重中之重。
Objective To investigate the relationship between prenatal screening, diagnosis and birth defects in Lanzhou from 2010 to 2015. Methods The report of prenatal screening, diagnosis, report of birth defects, report of perinatal infants in 8 counties in Lanzhou and Lanzhou New Area from October 1, 2009 to September 30, 2015 was collected. The Epi Data3.0 software to establish a database, and SPSS 16.0 software for statistical analysis. Results The number of prenatal screening, positive rate and prenatal diagnosis in Lanzhou in 2015 increased by 10 970, 45.44% and 31.94% respectively compared with that of 2010; with the increase of prenatal screening, the positive rate and prenatal diagnosis The increase in the diagnosis rate, the incidence of birth defects, the birth defect rate and the birth defect rate within 7 days also increased significantly, up by 48.32%, 57.02% and 57.27% respectively from 2010. Conclusion Prenatal screening and diagnosis plays an important role in preventing the birth of children with birth defects. It is the most important task to reduce the incidence of birth defects at present and in the future.