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药物的精神依赖性是评价一个药物滥用潜力的重要指标。目前，评价药物精神依赖性潜力的方法主要有３种：自身给药实验方法、药物辨别实验方法和位置偏爱实验方法。本实验运用这３种方法对羟甲苯太尼和盐酸二氢埃托啡的精神依赖性进行了系统的评价，结果表明羟甲芬太尼和盐酸二氢埃托啡的精神依赖性潜力分别为吗啡的１０００多倍和近万倍。这也证明强效的阿片类镇痛药的精神依赖性主要是由阿片μ受体介导的。对实验结果的相关性进行的比较表明３种行为药理学模型评价的结果具相关性。为其在药物精神依赖性评价方面的广泛应用提供了有力的依据。
The spiritual dependence of drugs is an important indicator of the potential of a drug abuse. At present, there are mainly three ways to evaluate the drug-dependent potential of drug: self-administration experiment method, drug discrimination experiment method and position preference experiment method. In this experiment, the three methods were used to evaluate the psychic dependence of hydroxytoluene and dihydroetorphine hydrochloride. The results showed that the psychic dependent potentials of oxymetazidine and dihydroetorphine hydrochloride were More than 1,000 times and nearly 10,000 times that of morphine. This also proves that the spiritual dependence of potent opioid analgesics is mainly mediated by opioid μ receptors. A comparison of the correlation of the experimental results shows that the results of the three behavioral pharmacological models are relevant. It provides a strong basis for its extensive application in the evaluation of drug dependence.