论文部分内容阅读
以抗CEA单克隆抗体C_(50)(2mg)标记放射性同位素~(131)Ⅰ(C_((50)~-)~(131)Ⅰ,放射剂量10Mci),注射入16例大肠癌的肿瘤瘤体内及其周围。用另10例大肠癌患者,单纯以放射性同位素~(131)Ⅰ溶液注射于大肠癌肿瘤内及周围作为对照。两组患者均于给药后48、72小时进行全身SPECT检查,了解肿瘤部位同位素聚集的量(占给予量的百分比),同时通过手术切除标本观察肿瘤细胞的坏死情况。结果:单抗组中的肿瘤部位的~(131)Ⅰ聚集艟为14.04±9.10％,对照组中为4.28±3.01％,两者相比具有显著性差异;单抗组16例给药后,有10例发生了中等度的肿瘤细胞坏死,4例发生了大面积的肿瘤细胞坏死,对照组中只有4例发生了中等度的细胞坏死,两组相比有显著性差异。作者认为放射免疫药物的局部应用,提高了药物在实体肿瘤部位的聚集,从而增强了导向药物对实体肿瘤细胞的杀伤作用。
Anti-CEA monoclonal antibody C_(50)(2mg) was used to label radioisotope(131)I(C_(50)~-)~(131)I, radiation dose of 10Mci) and injected into 16 cases of colorectal tumors. In and around the body. Another 10 patients with colorectal cancer were treated with radioactive isotope 131I solution injected into and around the colorectal tumors as controls. In both groups, whole body SPECT was performed 48 and 72 hours after administration to determine the amount of isotope aggregation (% of the dose) at the tumor site. At the same time, tumor necrosis was observed by surgical resection of the specimen. RESULTS: The concentration of ~(131)I accumulated in the tumor site in the monoclonal antibody group was 14.04±9.10%, and that in the control group was 4.28±3.01%. There was a significant difference between the two groups; in the monotherapy group, 16 cases were administered. Ten cases had moderate tumor cell necrosis, 4 cases had large area of tumor cell necrosis, and only 4 cases in the control group had moderate cell necrosis. There was a significant difference between the two groups. The authors believe that the local application of radioimmunotherapy improves the accumulation of drugs in solid tumor sites, thereby enhancing the killing effect of targeted drugs on solid tumor cells.