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持久性肺泡炎症多见于急性呼吸窘迫综合征(ARDS)患者,死亡率较高。其发生机制至今仍未完全明了。已知中性粒细胞可通过凋亡途径影响炎症反应过程。该研究旨在确定ARDS危险性或持续性ARDS患者的支气管肺泡灌洗液(BALF)能否调节中性粒细胞凋亡,ARDS发生前后BALF中凋亡抑制剂G-CSF和GM-CSF的浓度及其与临床结局的相关性。 作者选取20例有ARDS危险性和45例已确诊为ARDS的患者为研究对象。被确定有ARDS危险的患者在24小时内进行肺泡灌洗,72小时后重复灌洗1次。ARDS患者确诊24小时内即予以肺泡灌洗,之后在第3天、7天、14天重复灌洗。将正常外周血白细胞加入正常志愿者、ARDS危险性患者及ARDS患者的BALF中孵育过夜。中
Persistent alveolar inflammation more common in patients with acute respiratory distress syndrome (ARDS), the mortality rate is higher. The mechanism has not yet been fully understood. Neutrophils are known to affect the inflammatory response process through the apoptotic pathway. The aim of this study was to determine if bronchoalveolar lavage fluid (BALF) in patients with ARDS at risk or with persistent ARDS regulates neutrophil apoptosis. The concentrations of G-CSF and GM-CSF in BALF before and after ARDS And its correlation with clinical outcome. The authors selected 20 patients with ARDS risk and 45 patients have been diagnosed with ARDS as the research object. Patients determined to be at risk for ARDS were subjected to alveolar lavage within 24 hours and to repeated lavage 72 hours later. Alveolar lavage was performed within 24 hours after diagnosis of ARDS, followed by repeated lavages on days 3, 7 and 14. Normal peripheral white blood cells were added to normal volunteers, ARDS-challenged patients and ARDS patients in BALF overnight. in