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目的和方法 :ｂｃｒ/ａｂｌ嵌合基因是定位于人 9号染色体 9ｑ34上的ｃ -ａｂｌ基因和 2 2号染色体 2 2ｑ1 1上的ｂｃｒ基因因ｔ( 9:2 2 )易位 ,使相应断裂的基因发生融合所形成。它是ｐｈ染色体的分子基础 ,在慢粒白血病 (ＣＭＬ)发病中起重要作用。Ｂｃｒ/ａｂｌ嵌合基因编码
Purpose and Methods: The bcr / abl chimeric gene is the result of the t (9: 2 2) translocation of the c-abl gene located on chromosome 9q34 on human chromosome 9 and the bcr gene on chromosome 2 2q1l on chromosome 2, Gene fusion occurs. It is the molecular basis of ph chromosome and plays an important role in the pathogenesis of chronic myeloid leukemia (CML). Bcr / abl chimeric gene encoding