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目的探讨了培哚普利和吲哒帕胺对脑血管病患者的疗效;方法 146例脑血管病患者按照分层随机分组法随机分为两组,安慰机组和治疗组,安慰剂组给予安慰剂治疗,治疗组给予培多普利,耐受患者再给与吲哒帕胺进行治疗,为期5年,对患者的血压、脑卒中发生率以及危险性进行评估;结果与安慰剂组比较,治疗组患者血压显著下降,具有统计学意义(P<0.05)。治疗组患者脑卒中发生率明显低于安慰剂组,具有统计学意义(P<0.05)。在5年中,治疗组患者卒中危险性降低了61%。结论培哚普利和吲哒帕胺治疗脑血管患者长期疗效显著,值得临床推广使用。
Objective To investigate the effect of perindopril and indapamide in patients with cerebrovascular disease.Methods 146 patients with cerebrovascular disease were randomly divided into two groups according to the stratified randomization method: placebo group and treatment group, and placebo group received placebo The patients in the treatment group were treated with perindopril and the patients in the tolerated group were treated with indapamide for a period of 5 years. The patients’ blood pressure, stroke incidence and risk were evaluated. Results Compared with placebo group, treatment Blood pressure of patients decreased significantly, with statistical significance (P <0.05). The incidence of stroke in the treatment group was significantly lower than that in the placebo group, with statistical significance (P <0.05). In five years, the treatment group had a 61% reduction in the risk of stroke. Conclusion Perindopril and indapamide treatment of cerebrovascular patients with long-term effect is significant, worthy of clinical promotion and use.