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Purpose.A previous study has shown t hat the pulsatile oc-ular blood flow(POBF)in eyes with asymmetric age-related macular degeneration(AMD)differs.Whereas eyes with drusen have higher POBF than contralateral eyes with dis-ciform scarring,the POBF of eyes wit h drusen is lower rel-ative to contralateral eyes with choroidal neovascularization(CNV).This study was designed to assess whether the POBF of eyes with CNV changes after tr anspupillary ther-motherapy(TTT),using the contralateral eyes with d rusen or scarring without TTT as controls.Methods.In total,26patients with CNV in one eye and druse n or scarring in the other were enrolled in this prospective case series.Eyes with CNV were treated with TTT.POBF w as measured monthly in both eyes of each subject.Results.Before TTT,the POBF of eyes with CNV was 1179±317μl /min.After TTT,the POBF of CNV eyes had decrease d at 1month(1015±273μl /min,P=0.002)and 2months(945±398μl /min,P=0.011)of follow-up,but had rebounded at 3months(P=0.441)and 6months(P=0.084).Conclusions.These findings suggest that TTT decreases the pulsatile choroidal blood flow in eyes with CNV in patients with asymmetric AMD and the effects p ersist for 2months.POBF may be used as amodality to monitor the the rapeutic effects of CNV in asymmetric exudative AMD.
Purpose. Previous studies have shown t hat the pulsatile oc-ular blood flow (POBF) in eyes with asymmetric age-related macular degeneration (AMD). Differences in eyes with drusen have higher POBF than contralateral eyes with dis-ciform scarring, the POBF of eyes wit h drusen is lower rel-ative to contralateral eyes with choroidal neovascularization (CNV). This study was designed to assess whether the POBF of eyes with CNV changes after tr anspupillary ther-motherapy (TTT), using the contralateral eyes with d rusen or scarring without TTT as controls. Methods. Total, 26 patients with CNV in one eye and druse n or scarring in the other were enrolled in this prospective case series. Eyes with CNV were treated with TTT. POBF w as measured monthly in both eyes of each subject. Results prior to TTT, the POBF of eyes with CNV was 1179 ± 317 μl / min. After TTT, the POBF of CNV eyes had decrease d at 1 month (1015 ± 273 μl / min, P = 0.002) and 2 months (945 ± 398 μl / min, P = 0.011) of follow-up, but had rebounded at 3 months (P = 0. 441) and 6months (P = 0.084) .Conclusions.These findings suggest that TTT decreases the pulsatile choroidal blood flow in eyes with CNV in patients with asymmetric AMD and the effects p ersist for 2months.POBF may be used as amodality to monitor the the rapeutic effects of CNV in asymmetric exudative AMD.