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为了提高光动力疗法（ＰＤＴ）的治癌效果，应用ＰＤＴ与瘤内注射氟尿嘧啶（５－Ｆｕ）治疗小鼠前胃癌移植瘤。治疗后各组移植瘤细胞ＤＮＡ含量和标记指数（ＬＩ）均较治疗前明显减少，而联合治疗组的减少较单纯ＰＤＴ或瘤内注射５－Ｆｕ组更为显著。又应用ＰＤＴ治疗进展期食管、贲门癌患者８０例，并对其中４０例联合应用内镜下局部注射５－Ｆｕ。结果：ＰＤＴ组的近期显效率为２２．５％（９／４０），联合治疗组显效率为４５．０％（１８／４０），高于ＰＤＴ组（Ｐ＜０．０５）。病例随访１２月～１８月，联合治疗组的平均生存期（３７４天）较ＰＤＴ组（２６６天）延长（Ｐ＜０．０１）。认为ＰＤＴ与局部注射５－Ｆｕ联合治疗上消化道癌，能协同提高ＰＤＴ的治疗效果。
In order to improve the cancer treatment effect of photodynamic therapy (PDT), PDT and intratumoral injection of fluorouracil (5-Fu) were used to treat mouse forefoot gastric carcinoma. After treatment, the DNA content and labeling index (LI) of the transplanted tumor cells in each group were significantly reduced compared with before treatment, while the reduction in the combined treatment group was more significant than the pure PDT or intratumoral injection of 5-Fu group. In addition, PDT was used to treat 80 patients with advanced esophageal and cardiac cancers, and 40 of them were combined with 5-Fu by endoscopy. Results: The effective rate in the PDT group was 22.5% (9/40). The effective rate in the combined treatment group was 45.0% (18/40), which was higher than that in the PDT group (P<0.05). In the follow-up period from December to 18 months, the average survival time of the combined treatment group (374 days) was longer than that of the PDT group (266 days) (P<0.01). It is considered that PDT combined with local injection of 5-Fu in the treatment of upper gastrointestinal cancer can synergistically improve the therapeutic effect of PDT.