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目的：分析肺癌合并肌无力综合征（ELS）的临床特点并进行文献复习。方法：1965～1995年我院收治8例肺癌合并ELS病例，其中SCLC 6例NSCLC 2例；NSCLC Ⅱ期1 例，Ⅲ期1例，SCLC局限期6例。治疗方法中放疗＋化疗6例，单纯化疗1例，单纯放疗1例。结果：随诊率为100％，中位生存9个月。ELS与肿瘤治疗的关系 症状加重1／8，无改善1／8，好转4／8，消失2／8。无1例因ELS死亡。结论：对比ELS与重症肌无力在发病率、临床表现、诊断、治疗上的不同。手术、放疗、化疗可使部分肺癌合并ELS患者的ELS症状缓解。胍类，计明胺，钙类药物对症治疗有效。
Objective: To analyze the clinical features of lung cancer associated with myasthenic syndrome (ELS) and review the literature. Methods: Eight patients with lung cancer and ELS were treated in our hospital from 1965 to 1995, including 6 cases of SCLC and 2 cases of NSCLC, 1 case of NSCLC II, 1 case of III, and 6 cases of SCLC. Treatments included 6 cases of radiotherapy plus chemotherapy, 1 case of chemotherapy alone, and 1 case of radiotherapy alone. Results: The follow-up rate was 100%, with a median survival of 9 months. The relationship between ELS and tumor therapy: Symptoms worsened by 1/8, no improvement by 1/8, improvement by 4/8, and disappearance by 2/8. None of the cases died of ELS. Conclusions: The differences in incidence, clinical manifestations, diagnosis and treatment of ELS and myasthenia gravis were compared. Surgery, radiotherapy, and chemotherapy can relieve ELS symptoms in some lung cancer patients with ELS. Anthraquinones, diamines, and calcium drugs are effective for symptomatic treatment.