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目的探讨血清中游离脂肪酸(FFA)水平与糖尿病肾病(DN)的关系。方法将120例2型糖尿病(T2DM)患者分为合并DN组66例,单纯糖尿病(单纯DM)组54例;均检测其空腹血糖(FPG)、餐后2 h血糖(2h PG)、糖化血红蛋白(HbA1c)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、24 h尿微量白蛋白(MAU)和FFA水平,分析FFA与各检测指标的相关性。结果 DN组和单纯DM组FFA均升高,且DN组升高显著高于单纯DM组,差异有统计学意义(P<0.01)。结论 DN患者治疗前后的FFA与FPG、HbA1c、TG、24h MAU等指标变化有关。FFA升高可促进DN的发生、发展。
Objective To investigate the relationship between serum free fatty acid (FFA) and diabetic nephropathy (DN). Methods One hundred and twenty patients with type 2 diabetes mellitus (T2DM) were divided into 66 patients with DN group and 54 patients with simple diabetes mellitus group (DM). The levels of fasting blood glucose (FPG), 2h postprandial blood glucose (2h PG), glycosylated hemoglobin (HbA1c), total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), 24 h urine microalbumin (MAU) Level, analyze the correlation between FFA and each test index. Results The FFA in both DN group and DM group were significantly higher than those in DM group (P <0.01). Conclusion The levels of FFA in patients with DN before and after treatment are related to the changes of indicators such as FPG, HbA1c, TG and 24h MAU. Increased FFA can promote the occurrence and development of DN.