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肿瘤微环境(tumor microenvironment,TME)在肿瘤生长、血管生成、上皮-间质转化(epithelial-mesenchymal transition,EMT)、侵袭、迁移和转移中起着至关重要的作用。TME包含了几种不同的细胞类型,如癌相关成纤维细胞(cancey-associated fibroblasts,CAFs)、内皮细胞、周细胞、平滑肌细胞、中性粒细胞、巨噬细胞、脂肪细胞、树突状细胞、自然杀伤细胞、淋巴细胞等。此外,还有丰富的非细胞成分,如细胞因子、生长因子、激素和细胞外基质
Tumor microenvironment (TME) plays a crucial role in tumor growth, angiogenesis, epithelial-mesenchymal transition (EMT), invasion, migration and metastasis. TME contains several different cell types, such as cancer-associated fibroblasts (CAFs), endothelial cells, pericytes, smooth muscle cells, neutrophils, macrophages, adipocytes, dendritic cells Natural killer cells, lymphocytes and the like. In addition, there are abundant non-cellular components, such as cytokines, growth factors, hormones and extracellular matrix