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控制性卵巢超刺激反应低下或完全没有反应的妇女被称为低反应者。目前,对低反应者的助孕治疗结果不够满意。曾有报道,对于促卵泡成熟激素(FSH)基础分泌增加的低反应者,在黄体中期到月经期之间使用小剂量的decapeptyl可以提高雌二醇(E_2)峰值,增加采卵数和可用于转运的胚胎个数,提高着床率,降低自发性流产率。本文评价在月经开始时终止使用促性腺激素释放激素激动剂(GnRHa)伴以大剂量促性腺激素治疗,用作低反应者体外受精-胚胎移植(IVF-ET)卵巢刺激的妊娠结果。
Women with low or no response to controlled ovarian hyperstimulation are referred to as low responders. At present, the results of pregnancy-assisted treatment of low responders are not satisfied. It has been reported that using a small dose of decapeptyl between the mid luteal phase and the menstrual phase may increase the peak of estradiol (E 2), increase the number of oocytes retrieved and may be used in low responders with increased basal secretion of follicle-stimulating hormone (FSH) Transfer the number of embryos, improve implantation rate, reduce the spontaneous abortion rate. This article evaluates the termination of gnRHa with high-dose gonadotropin therapy at the onset of menstruation and as a pregnancy outcome for ovarian stimulation of IVF-ET in low responders.