论文部分内容阅读
目的探讨腹膜后多发性巨型脂肪瘤伴部分肉瘤变的临床病理学特点和鉴别诊断。方法回顾复习1例腹膜后多发性巨型脂肪瘤伴部分肉瘤变的临床资料、组织学形态和免疫组化表型。结果患者为男性,年龄67岁。腹部可及约20 cm×15 cm大小的包块。眼观:灰黄色组织一堆:20 cm×16 cm×3 cm及灰白灰红色结节一枚,大小25 cm×16 cm×5 cm肿块,另有灰白结节2枚,直径分别为6.5 cm及11.5 cm,部分表面有包膜,切面灰黄色,质软,实性。大部分切面灰黄色,质地软,局灶区域灰白灰红,质地稍硬。镜检:肿瘤细胞大部分为成熟的脂肪组织组成。过渡区脂肪细胞核深染,不透亮。恶性区细胞呈梭形排列,漩涡状,栅栏状,局灶可见少量粘液样基质,部分可见少量出血及坏死。可见脂母细胞和瘤巨细胞。免疫组化结果Vimentin(+)、S-100(+/-)、CD68、CD117、AE1/AE3、EMA、Desmin均为阴性。结论发生在机体深部的巨大脂肪瘤容易恶变。
Objective To investigate the clinicopathological characteristics and differential diagnosis of multiple retroperitoneal giant lipoma with partial sarcoma. Methods A retrospective review of 1 case of retroperitoneal multiple giant lipoma with partial sarcoma of clinical data, histological morphology and immunohistochemical phenotype. Results The patient was male, age 67 years. The abdomen can reach about 20 cm × 15 cm in size. Eye: a group of gray and yellow tissue: 20 cm × 16 cm × 3 cm and gray-gray red nodules, a size of 25 cm × 16 cm × 5 cm mass, and another gray nodules 2, diameter 6.5 cm And 11.5 cm, part of the surface of the envelope, cut grayish yellow, soft, solid. Most aspects of the gray-yellow, soft texture, grayish red focal area, slightly harder texture. Microscopic examination: most of the tumor cells are composed of mature adipose tissue. Transitional fat cell nucleus stained, not translucent. Malignant cells were spindle-shaped arrangement, swirling, palisading, focal visible a small amount of mucus-like matrix, part of a small amount of bleeding and necrosis can be seen. Shows the mother cells and tumor giant cells. Immunohistochemical results Vimentin (+), S-100 (+/-), CD68, CD117, AE1 / AE3, EMA, Desmin were negative. Conclusion The huge lipomas in the deep body of the body are prone to malignant transformation.