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目的 :观察神香苏合丸对狗急性心肌梗塞的影响。方法 :2 7只狗 ,分 4组 ,其中神香苏合丸分小剂量组和大剂量组 ,予以灌胃给药。狗麻醉后行气管插管 ,开胸分离冠状动脉前降支并行两步法结扎 ,4h后取心肌行NBT染色 ,确定心肌梗塞程度 ,并做阴性对照组和阳性对照组试验。结果 :狗冠状动脉前降支结扎后死亡率为 4 4.4 % ,而给大剂量神香苏合丸组的心肌梗塞后死亡率有明显下降趋势 (与阴性对照组比 ,P <0 .0 5) ,并能降低ST T的抬高程度 ,缩小心肌梗塞范围 ,与等同剂量的麝香保心丸阳性对照组结果相似。小剂量神香苏合丸组未能降低心肌梗塞后的死亡率 ,虽有降低ST T的抬高程度和缩小心肌梗塞范围 ,但未能达到显著的水平。结论 :口服神香苏合丸可显著降低狗急性心肌梗塞及其诱导心电图ST T的抬高程度 ,并缩小心肌梗塞范围
Objective : To observe the effect of Shenxiang Suhe Pill on acute myocardial infarction in dogs. Methods: Twenty-seven dogs were divided into 4 groups. The Shenxiang Suhe Pills were divided into small dose group and large dose group. After the dogs were anesthetized, they were intubated, and the thorax was isolated and the descending branch of the coronary artery was ligated in two steps. After 4 hours, the myocardium was taken for NBT staining to determine the degree of myocardial infarction. The negative control group and the positive control group were tested. RESULTS: The mortality rate after coronary artery ligation was 44.4 % in dogs, but the mortality after myocardial infarction was significantly decreased in large-dose Shenxiang Suhe Pills group (P<0.05 compared with negative control group). ), and can reduce the degree of ST T elevation, narrowing the scope of myocardial infarction, and the equivalent dose of Qixiang Baoxin Pills positive control group results are similar. Small-dose Shenxiang Suhe Pills failed to reduce the mortality rate after myocardial infarction. Although the ST T elevation was reduced and the myocardial infarction range was reduced, it failed to reach a significant level. Conclusion : Oral administration of Shenxiang Suhe Pills can significantly reduce the elevation of acute myocardial infarction in dogs and STT induced by electrocardiogram, and reduce the scope of myocardial infarction.