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最近几年,国內对口服锑剂治疗血吸虫病作了不少研究工作。但目前試用的口服銻剂腸溶片在腸內崩解后,由于崩解速度快,局部銻浓度高,常引起較严重的刺激和反应,又因銻释放不均,不能均勻吸收,以致影响疗效。我們在研究口服銻剂腸溶片的基础上,在酒石酸銻鉀(下簡称“銻鉀”)內加入不同的緩解剂,試制成片剂16种,并試驗了它們在人工腸液內崩解的速度及均匀度。現将我們的实驗报道如下。一、片剂制造方法处方成分:銻鉀、酒石酸氢鉀(銻鉀与本品的比例为1:2)、淀粉、糊精及蔗糖(每片含銻鉀
In recent years, the domestic antimony agent for oral treatment of schistosomiasis made a lot of research work. However, the current trial of oral antimony agent enteric-coated tablets in the intestine after disintegration, due to rapid disintegration, local high concentration of antimony, often cause more serious irritation and reaction, but also due to uneven release of antimony, can not be absorbed evenly, so that the impact Efficacy. We study the oral antimony agent enteric-coated tablets on the basis of antimony potassium tartrate (hereinafter referred to as “antimony potassium”) by adding different remediation agents, made into tablets of 16 species and tested them in artificial intestinal fluid Disintegration speed and uniformity. Now we report the experiment below. First, the tablet manufacturing method Prescription ingredients: antimony potassium, potassium hydrogen tartrate (antimony potassium and the ratio of 1: 2), starch, dextrin and sucrose (each containing antimony potassium