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目的通过对胎儿宫内发育迟缓(IUGR)儿与正常儿生后1岁内血清瘦素(Leptin)水平的动态监测,探讨瘦素在IUGR儿追赶生长中的作用。方法随机选择资料完整的新生儿83 例,其中IUGR组43例,正常组40例,进行跟踪随访,采用放免法测定血清瘦素水平。结果出生时IUGR儿血清瘦素水平(4．77±2．64)ng／ml,明显低于正常组(8．69±5．52)ng／ml,瘦素与体重指数(BMI)呈显著相关性(IUGR组r=0．37,P<0．01,正常组,r=0．57,P<0．001),随月龄增加, IUGR组BMI与正常组比较无显著性差异,而出生3、6、12个月IUGR组血清瘦素水平(ng／ml)明显上升,并显著高于正常组(3．97±1．94比3．42±1．56,4．29±1．09比3．78±1．15,4．11±0．98比 3．53±1．23),IUGR组瘦素水平与BMI无显著相关性,而正常组瘦素与:BMI有一定的相关性。结论 IUGR儿瘦素水平的升高可能与瘦素抵抗或脂肪组织功能缺陷有关,瘦素作为生长促进因子参与生后个体的发育,是IUGR儿发生追赶生长的主要原因。
Objective To investigate the role of leptin in catching up with IUGR children through dynamic monitoring of serum leptin in 1-year-old fetus (IUGR) and normal children. Methods Totally 83 neonates were selected randomly, including 43 cases in IUGR group and 40 cases in normal group. The patients were followed up and the serum leptin levels were measured by radioimmunoassay. Results The level of leptin and body mass index (BMI) at birth were significantly lower in IUGR children (4.77 ± 2.64) ng / ml than those in normal controls (8.69 ± 5.52) ng / ml (IUGR group, r = 0.37, P <0.01, normal group, r = 0.57, P <0.001). There was no significant difference in BMI between IUGR group and normal group However, the levels of serum leptin (ng / ml) in IUGR group at 3, 6 and 12 months after birth were significantly higher than those in normal group (3.97 ± 1.94 vs 3.42 ± 1.56, 4.29 ± 1.09 vs 3.78 ± 1.15, 4.11 ± 0.98 and 3.53 ± 1.23, respectively. There was no significant correlation between leptin level and BMI in IUGR group, but there was no difference between BMI and normal group A certain degree of relevance. Conclusions The increase of leptin levels in IUGR may be related to leptin resistance or dysfunction of adipose tissue. Leptin participates in the development of postnatal development as a growth promoting factor, which is the main reason for IUGR children to catch up with growth.